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Pharmacist Osinachi (B. Pharm, MPSN, QHSE, ASM

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*CBD and Bone Growth Research* A 2009 study concludes that in age-related osteoporosis, cannabinoid receptors will increase peak bone mass and bone marrow. Osteoporosis is defined as the loss of bone mass and bone tissue, creating weak bones. It is oftentimes in older people, specifically women due to smaller bones and menopause. Observations throughout the study demonstrate that the CB1 receptor regulates peak bone mass through effects of osteoclasts, bone resorption and age-related bone loss. This means that the administered CBD helped to strengthen the fracture callus; the cartilage which mends the fracture. The CB1 receptor is therefore unique in that it regulates peak bone mass through an effect on osteoclast activity, but protects against age-related bone loss by regulating bone cells. In one of the most recent studies, results show that CBD alone specifically helps with healing bone fractures. Tel Aviv University specifically examined the bone health with isolated CBD or a combination with THC; a group of mice were administered CBD or THC and CBD. Results concluded that isolated CBD has better effects than when the two cannabinoids were in combination. *During this study the results concluded that CBD alone enhanced the biochemical properties of healing in a fracture. CBD involves changes to the organic matrix of bones that affects the flexibility and toughness*. Multiple experiments were complete to isolate the various effects of how CBD helps with bone growth. *Findings show the callus has an increase in strength and toughness from CBD which is explained by osteoblastic bone formation*. *Endocannabinoid System and Bone Growth* Most of us are familiar with the endocannabinoid system but there is also a skeletal cannabinoid system that works with your bones. Some of the key components found in the endocannabinoid system are also located in our bones. Anandamide and 2AG are believed to be sourced in the skeleton and produced by osteoblasts and osteoclasts. CBD interacts with these cannabinoid receptors to return back to homeostasis. Anandamide: an endocannabinoid neurotransmitter that regulates pain, sleep, memory, reproduction, movement and cognition. 2AG: a main endocannabinoid that reacts on the CB receptors in the central and peripheral nervous system. 2AG regulates appetite, pain management and the immune system. These studies demonstrate how CBD and bone growth relate. Due to our skeletal endocannabinoid system, CBD is able to send signals to our bone cells. It is important to maintain a healthy lifestyle while your bones are healing so they can heal properly. CBD helps with bone growth to strengthen the bone by triggering osteoblasts. Once you get older your bone will begin to deteriorate causing your bones to become brittle, making it easier to fracture. Old age can also come with bone diseases that create a block in bone growth. Getting through life with a bone disease like osteoporosis typically means relying on medications to provide relief. Prescription medications can come with harsh side effects that make you feel even worse. Turning to a natural cannabinoid will eliminate having to take medications that provide poor side effects. Research shows direct correlation in CBD and bone growth.